Striatal Sensitivity During Reward Processing in Attention-Deficit/Hyperactivity Disorder
Journal of the American Academy of Child & Adolescent Psychiatry,
Paloyelis Y et al. – The findings challenge the idea of a deficit in anticipation–related activation in the ventral striatum in male adolescents with attention–deficit/hyperactivity disorder combined type (ADHD–CT), while suggesting that the processing of reward outcomes is dysfunctional, consistent with a recent neurobiological model of the disorder. Preliminary evidence suggests that polymorphic variations in genes affecting dopamine signaling need to be taken into consideration when investigating reward–related deficits in ADHD–CT.