Methylation capacity in children with severe cerebral palsy
European Journal of Clinical Investigation, 07/06/2012
Schoendorfer NC et al. – Raised MCV in the presence of elevated red cell folate, adequate B12 status and low plasma urate suggest potential methyltetrahydrofolate trapping and impaired purine synthesis. Well–documented malnutrition issues in O may explain differences between cerebral palsy (CP) groups. These data support the hypothesis of possible dysregulation in methylation capacity and/or folate one–carbon metabolism, although more research is needed to elucidate a precise mechanism.