Diastolic function parameters are improved by the addition of simvastatin to enalapril-based treatment in hypertensive individuals
Atherosclerosis,  Clinical Article

Beck ALS et al. – The addition of simvastatin to enalapril in hypertensive patients with average cholesterol levels improves parameters of diastolic function independently of changes in blood pressure or cholesterol.

Methods
  • Hypertensive patients with DD and LDL–cholesterol <160mg/dL underwent a run–in phase to achieve a systolic blood pressure (SBP) <135mmHg and diastolic blood pressure (DBP) <85mmHg with enalapril.
  • Hydrochlorothiazide was added when need to achieve blood pressure control.
  • Four weeks after reaching the optimum anti–hypertensive regimen patients were randomized to receive 80mg simvastatin (n=27) or placebo (n=28) for a period of 20 weeks.
  • Echocardiograms were performed before and after treatment with measurement of maximum left atrial volume (LAV), conventional and tissue Doppler velocities in early diastole (E, e’) and late diastole (A, a’).

Results
  • After 20 weeks, the simvastatin group presented reduction in SBP (–4±2mmHg, p=0.02), increase in E/A ratio (1.0±0.05 to 1.2±0.06, p=0.03) and decrease of LAV indexed to body surface area (24.5±0.9 to 21.1±0.8ml/m2, p=0.048), as compared with placebo arm.
  • No change in systolic function and no correlation between the E/A ratio, LAV and changes in blood pressure or lipid profile were observed.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nurse Practitioner

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nurse Practitioner Articles

1 The impact of patient suicide and sudden death on health care professionals General Hospital Psychiatry, October 27, 2014    Clinical Article
Exclusive Author Commentary

2 Prazosin in the treatment of PTSD Journal of Psychiatric Practice, July 24, 2014    Review Article

3 Vitamin D and sleep disorders Full Text Nature and Science of Sleep, August 13, 2014    Free full text    Clinical Article

4 Topical petrolatum gel alone versus topical silver sulfadiazine with standard gauze dressings for the treatment of superficial partial thickness burns in adults: A randomized controlled trial Burns, September 17, 2014    Clinical Article

5 Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: Results from the EPIC cohort study International Journal of Cancer, October 3, 2014    Clinical Article

6 Vitamin D and the risk of dementia and Alzheimer's disease Neurology®, August 27, 2014    Clinical Article

7 Habitual intake of fruit juice predicts central blood pressure Appetite, October 24, 2014    Clinical Article

8 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

9 Chocolate consumption and risk of heart failure in the Physicians Health Study European Journal of Heart Failure, October 17, 2014    Clinical Article

10 Fish consumption and risk of rheumatoid arthritis: A dose-response meta-analysis Arthritis Research & Therapy, October 7, 2014    Evidence Based Medicine    Review Article

11 Intake of fruit and vegetables and risk of bladder cancer: A dose-response meta-analysis of observational studies Cancer Causes and Control, October 10, 2014    Clinical Article

12 Determinants of vitamin D status in caucasian adults: Influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors Journal of Investigative Dermatology, October 21, 2014    Clinical Article

13 Coffee for morning hunger pangs. An examination of coffee and caffeine on appetite, gastric emptying, and energy intake Appetite, October 17, 2014    Clinical Article

14 Chocolate intake and diabetes risk Clinical Nutrition, October 27, 2014    Clinical Article

15 Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults Hypertension, September 26, 2014    Clinical Article

16 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

17 Vitamin D deficiency is associated with progression of knee osteoarthritis The Journal of Nutrition, October 9, 2014    Clinical Article

18 The use of dietary supplements in oncology Current Oncology Reports, October 7, 2014    Clinical Article

19 Effects of high-protein vs. high- fat snacks on appetite control, satiety, and eating initiation in healthy women Full Text Nutrition Journal, October 15, 2014    Free full text    Clinical Article

20 Red meat and fruit intake is prognostic among patients with localized cutaneous melanomas more than 1 mm thick Cancer Epidemiology, October 14, 2014    Clinical Article

Indexed Journals in Nurse Practitioner: Journal of the American Academy of Nurse Practitioners, Holistic Nursing Practicemore