Enhanced clopidogrel response in smokers is reversed after discontinuation as assessed by VerifyNow assay: additional evidence for the concept of smokers paradox
Heart,  Clinical Article

Park KW et al. – Enhanced clopidogrel response in smokers is reversed after smoking discontinuation, suggesting a causal relationship in addition to the previously reported association between smoking and enhanced clopidogrel response.

Methods
  • From the prospective CROSS–VERIFY cohort, 810 subjects with repeated measurement of OPR at least 1 month apart were analysed.
  • With smoking status ascertained at two time points, baseline and follow–up, study subjects were categorised into never smokers (n=628), smoking quitters (n=77) and persistent smokers (n=105).
  • Dependent variables included OPR measured by the VerifyNow assay and the percentage of subjects with high OPR (HOPR).

Results
  • At baseline, current smokers showed significantly lower OPR compared with never smokers, with no significant differences in OPR between future quitters and future persistent smokers within current smokers.
  • While the OPR of never smokers and persistent smokers did not change significantly during the follow–up, the mean OPR of quitters increased significantly by 19 P2Y12 reaction units (p=0.013).
  • The frequency of HOPR showed similar results, with an 8–10% increase in smoking quitters in contrast to no significant changes in never and persistent smokers.
  • Both mean OPR and the frequency of HOPR showed a linear inverse relationship with the amount of smoking.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nurse Practitioner

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nurse Practitioner Articles

1 The impact of patient suicide and sudden death on health care professionals General Hospital Psychiatry, October 27, 2014    Clinical Article
Exclusive Author Commentary

2 Prazosin in the treatment of PTSD Journal of Psychiatric Practice, July 24, 2014    Review Article

3 Vitamin D and sleep disorders Full Text Nature and Science of Sleep, August 13, 2014    Free full text    Clinical Article

4 Topical petrolatum gel alone versus topical silver sulfadiazine with standard gauze dressings for the treatment of superficial partial thickness burns in adults: A randomized controlled trial Burns, September 17, 2014    Clinical Article

5 Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: Results from the EPIC cohort study International Journal of Cancer, October 3, 2014    Clinical Article

6 Vitamin D and the risk of dementia and Alzheimer's disease Neurology®, August 27, 2014    Clinical Article

7 Habitual intake of fruit juice predicts central blood pressure Appetite, October 24, 2014    Clinical Article

8 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

9 Chocolate consumption and risk of heart failure in the Physicians Health Study European Journal of Heart Failure, October 17, 2014    Clinical Article

10 Fish consumption and risk of rheumatoid arthritis: A dose-response meta-analysis Arthritis Research & Therapy, October 7, 2014    Evidence Based Medicine    Review Article

11 Intake of fruit and vegetables and risk of bladder cancer: A dose-response meta-analysis of observational studies Cancer Causes and Control, October 10, 2014    Clinical Article

12 Determinants of vitamin D status in caucasian adults: Influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors Journal of Investigative Dermatology, October 21, 2014    Clinical Article

13 Coffee for morning hunger pangs. An examination of coffee and caffeine on appetite, gastric emptying, and energy intake Appetite, October 17, 2014    Clinical Article

14 Chocolate intake and diabetes risk Clinical Nutrition, October 27, 2014    Clinical Article

15 Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults Hypertension, September 26, 2014    Clinical Article

16 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

17 Vitamin D deficiency is associated with progression of knee osteoarthritis The Journal of Nutrition, October 9, 2014    Clinical Article

18 The use of dietary supplements in oncology Current Oncology Reports, October 7, 2014    Clinical Article

19 Effects of high-protein vs. high- fat snacks on appetite control, satiety, and eating initiation in healthy women Full Text Nutrition Journal, October 15, 2014    Free full text    Clinical Article

20 Red meat and fruit intake is prognostic among patients with localized cutaneous melanomas more than 1 mm thick Cancer Epidemiology, October 14, 2014    Clinical Article

Indexed Journals in Nurse Practitioner: Journal of the American Academy of Nurse Practitioners, Holistic Nursing Practicemore