mdlinx mdlinx
Latest (254) Full Text Articles (3822) Article Summary

Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: A pilot randomized, double-blind, placebo-controlled trial
Pediatric Critical Care,  Clinical Article

Bhutta AT et al. – The authors did not find any evidence for neuroprotection or neurotoxicity in the pilot study. A large, adequately powered randomized control trial is needed to discern the central nervous system effect of ketamine on the developing brain. brain.

Methods
  • The authors randomized 24 infants, without chromosomal abnormalities, to receive ketamine (2mg/kg, n=13) or placebo (saline, n=11) before cardiopulmonary bypass for repair of ventricular septal defects.
  • Plasma markers of inflammation and central nervous system injury were compared at the end of surgery, and 6, 24, and 48hrs after surgery.
  • Magnetic resonance imaging and spectroscopy before cardiopulmonary bypass and at the time of hospital discharge were performed in a subset of cases and controls (n=5 in each group).
  • Cerebral hemodynamics were monitored postoperatively using near–infrared spectroscopy, and neurodevelopmental outcomes were assessed using Bayley Scales of Infant Development–II before and 2–3wks after surgery.

Results
  • Statistically significant differences were noted in preoperative inspired oxygen levels, intraoperative cooling and postoperative temperature, respiratory rate, platelet count, and bicarbonate levels.
  • The peak concentration of C–reactive protein was lower in cases compared to controls at 24hrs (p=.048) and 48hrs (p=.001).
  • No significant differences were noted in the expression of various cytokines, chemokines, S100, and neuron–specific enolase between the cases and controls.
  • Magnetic resonance imaging with spectroscopy studies showed that ketamine administration led to a significant decrease in choline and glutamate plus glutamine/creatine in frontal white matter.
  • No statistically significant differences occurred between pre– and postoperative Bayley Scales of Infant Development–II scores.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Nurse Practitioner

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nurse Practitioner Articles

Last month's top read Top Articles of 2013

Indexed Journals in Nurse Practitioner: Journal of the American Academy of Nurse Practitioners, Holistic Nursing Practicemore

Other Topics in Nurse Practitioner

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close