Flumazenil Administration in Poisoned Pediatric Patients
Pediatric Emergency Care, 05/08/2012
Kreshak AA et al. – No flumazenil–associated seizures occurred among allegedly benzodiazepine– and non–benzodiazepine–poisoned pediatric patients aged 12years or younger.Methods
- Included patient were those aged 12years or younger who received flumazenil, who had evidence of clinical poisoning as defined by an altered mental status, and who were reported to the California Poison Control System for the period 1999 to 2008.
- Data variables were age, sex, seizure, death, acute exposure to a benzodiazepine, drugs of exposure, long-term use of benzodiazepines, history of a seizure disorder, mental status before flumazenil administration, and poison center recommendation of flumazenil (yes/no).
- Eighty-three patients were included.
- Forty-eight (58%) of this subset were female.
- Median age was 2years (range, 3months–12years).
- Seventy (84%) patients were younger than 5years.
- Of the 83 patients, 68 (82%) were allegedly exposed to a benzodiazepine; whereas, 12 (15%) had been allegedly exposed to a proconvulsant drug.
- No flumazenil-related seizures occurred (0% with 95% confidence interval, 0%–4%).
- The California Poison Control System recommended flumazenil use in 60 (72%) of the 83 cases, and 48 of these had been allegedly exposed to a benzodiazepine.