Histological chorioamnionitis and neurodevelopmental outcome in preterm infants
Journal of Perinatology, 05/11/2012
Soraisham AS et al. – Histological chorioamnionitis (HCA) is associated with increased risk of cerebral palsy at 30 to 42 months corrected age in preterm infants.
The study design is a retrospective cohort study with a prospective follow-up.
All surviving infants with birth gestational age <29 weeks, born between 2000 and 2006, who had a neurodevelopmental assessment at 30 to 42 months corrected age were included.
Of the 384 infants, 197 (51%) were born to mothers with evidence of HCA.
Infants with HCA were of lower gestational age (26 weeks vs 26.6 weeks) and more likely to have intraventricular hemorrhage (27.9% vs 14.4%), periventricular leukomalacia (2.5% vs 0%) and retinopathy of prematurity stage 3 (31.4% vs 22.4%).
On univariate analysis, infants with HCA were more likely to have cerebral palsy (12.6% vs 6.4%, P=0.04).
There was no significant difference in the incidence of cognitive delay, deafness, blindness, or total major disabilities between the two groups.
After adjusting for perinatal variables, HCA was associated with increased risk of cerebral palsy (odds ratio (OR): 2.45; 95% confidence interval (CI) 1.11 to 5.40), but not for total major disabilities (OR: 1.22; 95% CI: 0.64 to 2.34).
There was a trend towards increased risk of cerebral palsy with HCA with funisitis.
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