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New Biomarkers with Relevance to Leprosy Diagnosis Applicable in Areas Hyperendemic for Leprosy
The Journal of Immunology, 05/14/2012
Geluk A et al. – This study identifies M. leprae–unique Ags, particularly ML2478, as biomarker tools to measure M. leprae exposure using IFN–γ or IFN–inducible protein–10, and also shows that MCP–1, MIP–1β, and IL–1β can potentially distinguish pathogenic immune responses from those induced during asymptomatic exposure to M. leprae.