Measles-Containing Vaccines and Febrile Seizures in Children Age 4 to 6 Years Full Text
Klein NP et al. – This study provides reassurance that MMRV and MMR + V were not associated with increased risk of febrile seizures among 4– to 6–year–olds.Methods
- Among 4- to 6-year-old Vaccine Safety Datalink members, they identified seizures in the emergency department and hospital from 2000 to 2008 and outpatient visits for fever from 2006 to 2008 during days 7 to 10 and 0 to 42 after MMRV and MMR + V.
- Incorporating medical record reviews, they assessed seizure risk after MMRV and MMR + V.
- From 2006 through 2008, 86?750 children received MMRV; from 2000 through 2008, 67438 received same-day MMR + V.
- Seizures were rare throughout days 0 to 42 without peaking during days 7 to 10.
- There was 1 febrile seizure 7 to 10 days after MMRV and 0 after MMR + V.
- Febrile seizure risk was 1 per 86750 MMRV doses and 0 per 67438 MMR + V doses.