Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with Type 2 diabetes uncontrolled by oral agents
Journal of Diabetes and its Complications,  Clinical Article

Sakharova OV et al. - In type 2 diabetes patients failing oral anti-hyperglycemic drugs (OADs) therapy, an initial insulin regimen of twice daily premixed insulin results in significantly improved post-prandial glucose levels as well as a reduction in a precursor of AGEs. The effect of these two initial insulin regimens on long-term diabetic complications requires further study.

Methods
  • This was a 6-month, open-label, single-center study using a cross-over design.
  • 14 subjects were randomized to one of two protocols: once daily insulin glargine or twice-daily 75%/25% neutral protamine lispro/lispro mix.
  • At 12 weeks, the subjects were crossed-over to the opposite protocol.
  • During each period, insulin doses were titrated to target fasting blood glucose of 90–110mg/dL.
  • At baseline and after the two 12-week treatment periods, subjects were studied in the Clinical Research Center; they consumed three liquid mixed isocaloric meals at 4-h intervals, and glucose, free fatty acids (FFA), lipids, and α-dicarbonyls (3-deoxyglucosone [3-DG] and methylglyoxal [MG]) were measured before and after each meal.
  • Patient data were analyzed in the context of their assigned insulin strategy groups.

Results
  • Both insulin regimens led to a significant improvement in glycemic profiles, including fasting glucose and HbA1c, compared to baseline.
  • However, mean post-prandial glucose was lower with lispro mix than with glargine (153±36 vs. 199±49 mg/dL, respectively; P=0.001).
  • Likewise, there was a reduction in both fasting (48±13 vs. 57±19, P=0.047) and post-prandial (53±19 vs. 63±23; P=0.007) 3DG levels with lispro mix as compared to glargine.
  • No differences were noted in MG concentrations.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nurse Practitioner

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nurse Practitioner Articles

1 Re-evaluating the role of antidepressants in cancer-related depression: A systematic review and meta-analysis General Hospital Psychiatry, June 3, 2014    Evidence Based Medicine

2 Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies Nutrition, Metabolism & Cardiovascular Diseases, July 25, 2014    Evidence Based Medicine    Clinical Article

3 Chocolate intake and diabetes risk Clinical Nutrition, July 21, 2014    Clinical Article

4 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 15, 2014    Clinical Article

5 Nut consumption for vascular health and cognitive function Nutrition Research Reviews, July 11, 2014    Review Article

6 The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients Journal of Crohn's and Colitis, June 11, 2014    Clinical Article

7 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Clinical Article

8 Obesity, adipose tissue function and the role of vitamin D Central European Journal of Immunology, July 14, 2014    Review Article

9 Risk of myocardial infarction and stroke in bipolar disorder: A systematic review and exploratory meta-analysis Acta Psychiatrica Scandinavica, May 30, 2014    Evidence Based Medicine    Review Article

10 Fruit and vegetable intake and risk of wheezing and asthma: A systematic review and meta-analysis Nutrition Reviews, July 1, 2014    Evidence Based Medicine

11 Partly replacing meat protein with soy protein alters insulin resistance and blood lipids in postmenopausal women with abdominal obesity The Journal of Nutrition, July 23, 2014    Clinical Article

12 Yogurt and weight management American Journal of Clinical Nutrition, April 3, 2014    Review Article

13 Alternate day fasting for weight loss in normal weight and overweight subjects: A randomized controlled trial Full Text Nutrition Journal, November 27, 2013    Free full text    Clinical Article

14 Mediterranean dietary pattern, inflammation and endothelial function: A systematic review and meta-analysis of intervention trials Nutrition, Metabolism & Cardiovascular Diseases, July 29, 2014    Evidence Based Medicine    Review Article    Clinical Article

15 Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS Metabolism, July 22, 2014    Clinical Article

16 Seafood consumption and umbilical cord blood mercury concentrations in a multiethnic maternal and child health cohort Full Text BMC Pregnancy and Childbirth, July 3, 2014    Free full text    Clinical Article

17 Association of tea consumption and the risk of oral cancer: A meta-analysis Oral Oncology , January 10, 2014    Evidence Based Medicine

18 Prospective association between red and processed meat intakes and breast cancer risk: modulation by an antioxidant supplementation in the SU.VI.MAX randomized controlled trial International Journal of Epidemiology, July 8, 2014    Clinical Article

19 Yoga therapy and ambulatory multiple sclerosis; assessment of gait analysis parameters, fatigue and balance Journal of Bodywork & Movement Therapies , July 14, 2014    Clinical Article

20 Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies American Journal of Clinical Nutrition, June 30, 2014    Clinical Article

Indexed Journals in Nurse Practitioner: Journal of the American Academy of Nurse Practitioners, Holistic Nursing Practicemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close