Anti-aging Effects of Alpha-Naphthoflavone on Normal and UVB-irradiated Human Skin Fibroblasts
Experimental Dermatology, 05/01/2012
Liao PL et al. – The authors concluded that α–NF promotes pro–collagen production and inhibits MMP–1 expression via the activation of a PI3K/Akt/Smad–3 pathway in normal and UVB–irradiated human skin fibroblasts, while TGF–β may play an important role in transducing this pathway. These results suggest that α–NF, a natural plant product, has the potential to become a novel anti–aging skin application.