Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways

The Journal of Allergy and Clinical Immunology, 05/01/2012

Imidazoquinolines (IMQs) Toll–like receptor (TLR)8 agonists engage adenosine–refractory TLR8 and inflammasome pathways to induce robust monocyte and monocyte–derived dendritic cells (MoDCs) activation and represent promising neonatal adjuvants.

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