mdlinx mdlinx
Latest (226) Full Text Articles (3822) Article Summary

Eplerenone and atrial fibrillation in mild systolic heart failure: results from the emphasis-HF (eplerenone in mild patients hospitalization and survival study in heart failure) study Full Text
JACC - Journal of the American College of Cardiology,  Clinical Article

Swedberg K et al. – In patients with systolic heart failure and mild symptoms, eplerenone reduced the incidence of new onset atrial fibrillation or flutter (AFF). The effects of eplerenone on the reduction of major cardiovascular (CV) events were similar in patients with and without AFF at baseline.

Methods
  • Patients in New York Heart Association functional class II and with ejection fraction 35% were eligible for EMPHASIS–HF.
  • History of AFF at baseline was reported by investigators using the study case report form.
  • New onset AFF (in those with no history of AFF at baseline) was reported using a specific endpoint form; in a sensitivity analysis authors also examined the effect of eplerenone on AFF reported as an adverse event.

Results
  • New onset AFF was significantly reduced by eplerenone: 25 of 911 (2.7%) versus 40 of 883 (4.5%) in the placebo group (hazard ratio [HR]: 0.58, 95% confidence interval [CI]: 0.35 to 0.96; p = 0.034).
  • The reduction in the primary endpoint with eplerenone was similar among patients with and without AFF at baseline (HR: 0.60, 95% CI: 0.46 to 0.79 vs. HR: 0.70, 95% CI: 0.57 to 0.85, respectively; p for interaction = 0.41).
  • The risk of cardiovascular (CV) death or hospital admission for worsening heart failure, the primary endpoint, was not significantly different in subjects with and without AFF at baseline (both study groups combined: HR: 1.23, 95% CI: 0.81 to 1.86; p = 0.33).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nurse Practitioner

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nurse Practitioner Articles

Last month's top read Top Articles of 2013

1 Evidence-informed frameworks for cost-effective cancer care and prevention in low, middle, and high-income countries The Lancet Oncology, March 10, 2014    Clinical Article

2 Tea consumption and leukemia risk: A meta-analysis Tumor Biology, February 12, 2014    Evidence Based Medicine    Clinical Article

3 Vitamin D and cardiovascular disease Circulation Research, February 3, 2014    Review Article    Clinical Article

4 Vitamin D deficiency in alopecia areata British Journal of Dermatology, March 24, 2014    Clinical Article

5 Coffee intake and gastric cancer risk Cancer Epidemiology, Biomarkers & Prevention, March 19, 2014    Clinical Article

6 Egg consumption and risk of GI neoplasms: dose–response meta-analysis and systematic review European Journal of Nutrition, February 6, 2014    Evidence Based Medicine    Review Article

7 Alternate day fasting for weight loss in normal weight and overweight subjects: A randomized controlled trial Full Text Nutrition Journal, November 27, 2013    Free full text    Clinical Article

8 Meta-analysis of vitamin D sufficiency for improving survival of patients with breast cancer Anticancer Research, March 14, 2014    Evidence Based Medicine    Clinical Article

9 Meat consumption and the risk of hepatocellular carcinoma Alimentary Pharmacology and Therapeutics, March 6, 2014    Review Article

10 Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: An updated systematic evidence review for the U.S. preventive services task force Annals of Internal Medicine, November 13, 2013    Evidence Based Medicine    Clinical Article

11 Aspirin use in heart failure Circulation: Heart Failure, March 19, 2014    Clinical Article

12 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

13 Role of walnuts in maintaining brain health with age The Journal of Nutrition, February 21, 2014    Review Article

14 Yogurt consumption and impact on health: focus on children and cardiometabolic risk American Journal of Clinical Nutrition, March 21, 2014    Review Article

15 Dairy intake and semen quality among men attending a fertility clinic Fertility and Sterility, March 20, 2014    Clinical Article

16 Effects of yoga on cardiovascular disease risk factors: A systematic review and meta-analysis International Journal of Cardiology, March 17, 2014    Evidence Based Medicine    Review Article    Clinical Article

17 Tea consumption and the risk of five major cancers: A dose-response meta-analysis of prospective studies Full Text BMC Cancer, March 18, 2014    Free full text    Evidence Based Medicine    Review Article

18 Is ginger effective for the treatment of irritable bowel syndrome? A double blind randomized controlled pilot trial Complementary Therapies in Medicine, March 4, 2014    Clinical Article

19 Egg consumption and cardiovascular disease among diabetic individuals: A systematic review of the literature Full Text Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, March 28, 2014    Free full text    Review Article

20 Tracheoplasty using the thymus against tracheo-esophageal fistula due to necrotizing tracheobronchitis in a very low birth weight infant Pediatric Pulmonology, March 12, 2014

Indexed Journals in Nurse Practitioner: Journal of the American Academy of Nurse Practitioners, Holistic Nursing Practicemore

Other Topics in Nurse Practitioner

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close