Factors Associated With Nonadherence to Thiopurines in Adolescent and Adult Patients With Inflammatory Bowel Disease

Journal of Pediatric Gastroenterology and Nutrition, 04/24/2012

Kamperidis N et al. – Adolescents are more frequently nonadherent than adults: prospective studies are required to determine the reasons for nonadherence in adolescents.

Methods

  • The authors sought factors associated with thiopurine nonadherence defined by thiopurine metabolite levels.

Results

  • Multivariate logistic regression confirmed that adolescents (odds ratio [OR] 4.6 [95% confidence interval [CI] 1.9–11.5]; P<0.01) compared with adults, patients with Crohn disease (OR 3.3 [CI 1.1–10.5] P=0.04) compared with ulcerative colitis, and patients living in more socially deprived areas (OR 1.03 [CI 1.0–1.1] P=0.02) were more likely to be nonadherent to thiopurines.

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