Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans
Cardiovascular Therapeutics, 04/30/2012
Bucci M et al. – In obese subjects, authors demonstrate that myocardial intracellular triglyceride oxidation significantly provides FA–derived energy for mechanical work. Trimetazidine (TMZ) reduced the oxidation of triglyceride–derived myocardial FAs improving myocardial efficiency.