Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans

Cardiovascular Therapeutics, 04/30/2012

In obese subjects, authors demonstrate that myocardial intracellular triglyceride oxidation significantly provides FA–derived energy for mechanical work. Trimetazidine (TMZ) reduced the oxidation of triglyceride–derived myocardial FAs improving myocardial efficiency.

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