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Association of adrenergic receptor gene polymorphisms with adolescent obesity in Taiwan
Pediatrics International, 05/01/2012
Chou YC et al. – Arg16Gly polymorphism of ADRB2 was significantly associated with obesity in female adolescents, and those with the Gly/Gly genotype were associated with a lower possibility of obesity and lower BMI. This polymorphism was also associated with a lower probability of hypertension in obese adolescents. The other two polymorphisms of ADRB (Gln27Glu and Trp64Arg) were not associated with adolescent obesity in Taiwan.
Methods- A total of 559 adolescent volunteers with equal numbers female and male were enrolled.
- Participants were divided into two groups: obese and normal weight (BMI 15th–85th percentile).
- Genomic DNA was extracted from buccal mucosa cells and genotyped in TaqMan assays.
- Genotype results and clinical subject characteristics were analyzed.
- Among the three ADRB polymorphisms, only Arg16Gly polymorphism was found to be significantly correlated with adolescent obesity, especially in girls.
- Girls with genotype Gly/Gly had a lower probability of obesity than those with genotypes Arg/Gly or Arg/Arg (P= 0.006; Arg/Gly: odds ratio [OR], 2.57, 95% confidence interval [95%CI]: 1.22–5.41; Arg/Arg: OR, 3.03, 95%CI: 1.50–6.12).
- Girls with genotype Gly/Gly had lower BMI than those with genotype Arg/Arg (P= 0.049).
- Obese adolescents with genotype Gly/Gly had a lower probability of hypertension than those with genotype Arg/Gly or Arg/Arg (P= 0.005).