Pretherapeutic uracil and dihydrouracil levels of colorectal cancer patients are associated with sex and toxic side effects during adjuvant 5-flurorouracil-based chemotherapy

Cancer, 04/19/2012

Pretherapeutic Ura and UH2 levels per se may be related to risk of side effects during adjuvant 5–fluorouracil (5–FU)–based treatment, whereas the UH2/Ura ratio may not always reveal such a risk. Sex is a strong risk factor for toxicity, showing the importance of evaluating male and female patients separately.

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