Proton Pump Inhibitor Use and Recurrent Clostridium difficile-associated Disease: A Case-control Analysis Matched by Propensity Score
Journal of Clinical Gastroenterology,  Clinical Article

Kim YJ et al. – Among the matched patient groups, only proton pump inhibitors (PPIs) therapy was associated with recurrent Clostridium difficile–associated disease (CDAD). Prospective studies are needed to clarify whether avoidance of PPIs or specific cotherapies will reduce the incidence of recurrent C. difficile–associated diarrhea.

Methods
  • This was a retrospective case-control study of patients with CDAD at Yeungnam University Medical Center, seen from January 2004 to December 2008.
  • C. difficile infection was diagnosed by the presence of C. difficile toxin in the stool.
  • Those with recurrent disease were matched with nonrecurrent controls using multivariate matched sampling methods that incorporated the propensity score.

Results
  • Recurrent CDAD developed in 28 (14.1%) of the 198 patients with diarrhea and positive C. difficile stool toxin assays.
  • Multivariate analysis of the total population of recurrent versus nonrecurrent CDAD revealed that additional use of non-C. difficile antimicrobial therapy (concomitant with the treatment or after or both), poor response to therapy with metronidazole or vancomycin, and recent gastrointestinal surgery were risk factors for recurrent CDAD.
  • The authors were able to match 21 recurrent CDAD subjects with 21 without recurrent CDAD.
  • Among the matched patients only PPI use was associated with recurrent CDAD (ie, 47.6% vs. 4.8%, P=0.004 for recurrent vs. nonrecurrent CDAD, respectively).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nurse Practitioner

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nurse Practitioner Articles

1 Re-evaluating the role of antidepressants in cancer-related depression: A systematic review and meta-analysis General Hospital Psychiatry, June 3, 2014    Evidence Based Medicine

2 Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies Nutrition, Metabolism & Cardiovascular Diseases, July 25, 2014    Evidence Based Medicine    Clinical Article

3 Chocolate intake and diabetes risk Clinical Nutrition, July 21, 2014    Clinical Article

4 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 15, 2014    Clinical Article

5 Nut consumption for vascular health and cognitive function Nutrition Research Reviews, July 11, 2014    Review Article

6 The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients Journal of Crohn's and Colitis, June 11, 2014    Clinical Article

7 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Clinical Article

8 Obesity, adipose tissue function and the role of vitamin D Central European Journal of Immunology, July 14, 2014    Review Article

9 Risk of myocardial infarction and stroke in bipolar disorder: A systematic review and exploratory meta-analysis Acta Psychiatrica Scandinavica, May 30, 2014    Evidence Based Medicine    Review Article

10 Fruit and vegetable intake and risk of wheezing and asthma: A systematic review and meta-analysis Nutrition Reviews, July 1, 2014    Evidence Based Medicine

11 Partly replacing meat protein with soy protein alters insulin resistance and blood lipids in postmenopausal women with abdominal obesity The Journal of Nutrition, July 23, 2014    Clinical Article

12 Yogurt and weight management American Journal of Clinical Nutrition, April 3, 2014    Review Article

13 Alternate day fasting for weight loss in normal weight and overweight subjects: A randomized controlled trial Full Text Nutrition Journal, November 27, 2013    Free full text    Clinical Article

14 Mediterranean dietary pattern, inflammation and endothelial function: A systematic review and meta-analysis of intervention trials Nutrition, Metabolism & Cardiovascular Diseases, July 29, 2014    Evidence Based Medicine    Review Article    Clinical Article

15 Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS Metabolism, July 22, 2014    Clinical Article

16 Seafood consumption and umbilical cord blood mercury concentrations in a multiethnic maternal and child health cohort Full Text BMC Pregnancy and Childbirth, July 3, 2014    Free full text    Clinical Article

17 Association of tea consumption and the risk of oral cancer: A meta-analysis Oral Oncology , January 10, 2014    Evidence Based Medicine

18 Prospective association between red and processed meat intakes and breast cancer risk: modulation by an antioxidant supplementation in the SU.VI.MAX randomized controlled trial International Journal of Epidemiology, July 8, 2014    Clinical Article

19 Yoga therapy and ambulatory multiple sclerosis; assessment of gait analysis parameters, fatigue and balance Journal of Bodywork & Movement Therapies , July 14, 2014    Clinical Article

20 Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies American Journal of Clinical Nutrition, June 30, 2014    Clinical Article

Indexed Journals in Nurse Practitioner: Journal of the American Academy of Nurse Practitioners, Holistic Nursing Practicemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close