Lapatinib, a dual inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2, potentiates the antitumor effects of cisplatin on esophageal carcinoma
Diseases of the Esophagus,  Clinical Article

Guo XF et al. – The findings indicated that the combination of lapatinib and cisplatin is one of the promising treatment strategies for esophageal carcinomas with epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) overexpression.

  • Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) overexpression occurs in over 30% of esophageal carcinomas.
  • Combination therapies of EGFR- and HER2-targeting agents with cytotoxic agents are considered a potential therapeutic strategy for esophageal cancer.
  • The antitumor effects of lapatinib, a dual tyrosine kinase inhibitor of EGFR and HER2, cisplatin alone, and the combination of the two drugs on esophageal cancer cells were evaluated.
  • The growth inhibition activity of lapatinib, cisplatin, and lapatinib plus cisplatin was measured by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assays, and the combination index values were calculated.
  • Additionally, cell cycle distribution and cell apoptosis treated with lapatinib or cisplatin alone and the combination of the two drugs were detected by flow cytometry analysis.
  • The activation of EGFR and HER2 signaling pathways was monitored by Western blot analysis.
  • These experimental data showed that the combination of lapatinib and cisplatin synergistically inhibited cell proliferation and exhibited an enhanced pro-apoptotic effect on esophageal cancer cells.
  • The underlying mechanisms of potentiated effects of combined treatment were associated with reduced phosphorylation of EGFR and HER2, and the downstream signaling molecules AKT and extracellular regulated protein kinases (ERK).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nurse Practitioner

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nurse Practitioner Articles

1 Chocolate intake and diabetes risk Clinical Nutrition, October 27, 2014    Clinical Article

2 Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study European Journal of Nutrition, November 21, 2014    Clinical Article

3 Consumption of garlic and risk of colorectal cancer: An updated meta-analysis of prospective studies Full Text World Journal of Gastroenterology, November 18, 2014    Free full text    Evidence Based Medicine

4 Dietary flavonoid intake at midlife and healthy aging in women American Journal of Clinical Nutrition, November 7, 2014    Clinical Article

5 The impact of patient suicide and sudden death on health care professionals General Hospital Psychiatry, October 27, 2014    Clinical Article
Exclusive Author Commentary

6 Vitamin D deficiency predicts cognitive decline in older men and women: The Pro.V.A. Study Neurology®, November 19, 2014    Clinical Article

7 Dairy product consumption and gastric cancer risk: A meta-analysis Full Text World Journal of Gastroenterology, November 14, 2014    Free full text    Evidence Based Medicine

8 Coffee for morning hunger pangs. An examination of coffee and caffeine on appetite, gastric emptying, and energy intake Appetite, October 17, 2014    Clinical Article

9 The effect of music therapy on cognitive functioning among older adults: a systematic review and meta-analysis Journal of the American Medical Directors Association, November 25, 2014    Evidence Based Medicine    Review Article

10 Fish consumption and risk of gastrointestinal cancers: A meta-analysis of cohort studies Full Text World Journal of Gastroenterology, November 17, 2014    Free full text    Evidence Based Medicine

11 Multivitamin use and cardiovascular disease in a prospective study of women American Journal of Clinical Nutrition, November 24, 2014    Clinical Article

12 Vegetarian diets and glycemic control in diabetes: A systematic review and meta-analysis Full Text Cardiovascular Diagnosis and Therapy, November 20, 2014    Free full text    Evidence Based Medicine    Review Article

13 Fruit and vegetable intake and rate of heart failure: A population-based prospective cohort of women European Journal of Heart Failure, November 12, 2014    Clinical Article

14 Results of 2-year vitamin B treatment on cognitive performance: Secondary data from an RCT Neurology®, November 21, 2014    Clinical Article

15 Milk intake and risk of mortality and fractures in women and men: cohort studies BMJ, November 11, 2014    Evidence Based Medicine    Clinical Article

16 Vitamin D and pregnancy outcomes Current Opinion in Obstetrics and Gynecology, November 14, 2014    Review Article

17 Dairy products, calcium, and prostate cancer risk: A systematic review and meta-analysis of cohort studies American Journal of Clinical Nutrition, November 26, 2014    Clinical Article

18 Rheological characteristics of cold thickened beverages containing xanthan gum–based food thickeners used for dysphagia diets Journal of the Academy of Nutrition and Dietetics, November 24, 2014    Clinical Article

19 Vitamin and mineral supplements The Journal of the American Dental Association , November 3, 2014    Evidence Based Medicine    Clinical Article

20 The low-FODMAP diet: An approach for controlling irritable bowel syndrome Topics in Clinical Nutrition, November 21, 2014    Clinical Article

Indexed Journals in Nurse Practitioner: Journal of the American Academy of Nurse Practitioners, Holistic Nursing Practicemore