The metastatic microenvironment. Brain-derived soluble factors alter the malignant phenotype of cutaneous and brain- metastasizing melanoma cells
International Journal of Cancer, 04/13/2012
Klein A et al. – Brain–derived soluble factors enhanced the transmigration, across human brain endothelial cells of cutaneous but not of brain–metastasizing melanoma variants. This activity could promote the capacity of the cutaneous cells to metastasize to the brain.