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Angiogenesis related gene expression profiles of EA.hy926 cells induced by irbesartan: a possible novel therapeutic approach

Cong M et al. – The study showed that irbesartan may induce angiogenic effects in vascular endothelial cells. It suggested that the mechanism of angiogenic effects of Angiotensin II type 1 receptor blockers might be attributed to the signaling cascade from angiotensin receptors in the VEGF pathway. It also provided evidence indicating that Angiotensin II type 1 receptor blockers could be used as a novel therapeutic approach to treat chronic ischemic heart disease as well as anti–hypertensive agents. [more...]