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Below you will find bonus content hand-picked by our senior medical editor, D. Scott Cunningham, MD, Ph.D, as well as clinical pearls derived from our Internal Medicine Review. All this plus more, free with your membership.
Rho-associated kinase activity is a biomarker for cardiovascular events
As reported in Hypertension, rho-associated kinase activity is an independent predictor of cardiovascular events. The study involved 633 patients undergoing routine health screening examinations with a median follow-up of 42 months. There were 29 cardiovascular-related deaths, 2 myocardial infarctions, 20 revascularizations, 15 strokes, and 17 hospitalizations for heart failure. The HRs for first cardiovascular event, death, stroke, and revascularization were 2.19, 2.57, 2.14, and 2.68, respectively.
Calcium reduces CRC risk
As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.
sCD40L suggests sub-clinical atherosclerosis in psoriasis
As reported in the International Journal of Dermatology, sCD40L levels are elevated and brachial artery flow-mediated dilation is decreased in patients with chronic plaque-type psoriasis (n=56) without known cardiovascular disease compared to healthy controls.