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See Latest ArticlesFOXE1 is a target for aberrant methylation in cutaneous squamous cell carcinoma
British Journal of Dermatology, 12/14/09
Teti D et al. – The authors found a higher frequency of FOXE1 promoter hypermethylation in SCCs (55%), as compared with the adjacent uninvolved skin (12%) and blood control samples (9·5%). FOXE1 methylation was frequently seen in association with a complete absence of or downregulated gene expression. Treatment with the demethylating agent 5–Aza–2'–deoxycytidine resulted in profound reactivation of FOXE1 expression.
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