Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Use of Antiemetic Agents in Acute Gastroenteritis 3. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 4. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease 5. Rapid correction of low vitamin D status in nursing home residents
Your Article Summary
See Latest ArticlesThe global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation
Diabetologia - Clinical and Experimental Diabetes and Metabolism, 11/09/09
Kolb H et al. – The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary lifestyle, sleep deprivation and depression) have been found to induce local or systemic low–grade inflammation that is usually transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in the pancreatic islets. Chronic low–grade inflammation will eventually lead to overt diabetes if counter–regulatory circuits to inflammation and metabolic stress are compromised because of a genetic and/or epigenetic predisposition. Hence, it is not the lifestyle change per se but a deficient counter–regulatory response in predisposed individuals which is crucial to disease pathogenesis. Novel approaches of intervention may target these deficient defence mechanisms.
Related Articles
Hepatic fat and inflammation in type 2 diabetes mellitus
Metabolism-Clinical and Experimental, 10/26/09
Relevance Score: 82%
Value of C-reactive protein and IL-6 measurements in type 1 diabetes mellitus
Archives of Medical Science, 11/02/09
Relevance Score: 81%
Gender differences in adiponectin and low-grade inflammation among individuals with normal glucose tolerance, prediabetes, and type 2 diabetes
Gender Medicine, 10/21/09
Relevance Score: 80%
Effect of pioglitazone on systemic inflammation is independent of metabolic control and cardiac autonomic function in patients with type 2 diabetes
Acta Diabetologia, 10/08/09
Relevance Score: 80%
Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease
European Heart Journal, 10/01/09
Relevance Score: 79%
Today in General Medicine...keeping you current
Receive free subspecialty "5-minute updates" via email
Prevalence of Wet-to-Dry Dressings in Wound Care
Advances in Skin & Wound Care: The Journal for Prevention and Healing, 12/07/09
Acute pancreatitis: Problems in adherence to guidelines
Cleveland Clinic Journal of Medicine, 12/02/09
Marfan syndrome
Journal of the American Academy of Nurse Practitioners, 12/02/09
Today in Preventive Medicine...keeping you current
Receive free subspecialty "5-minute updates" via email
Dietary intake of trans fatty acids as a cardiovascular risk factor in a population of Italian teenagers
Cardiology in the Young, 12/07/09
Pioglitazone and mechanisms of CV protection
QJM: An International Journal of Medicine, 12/07/09
Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies
British Medical Journal, 12/07/09
Sponsor
Article Search
Sponsor
Sponsor