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Hocker B et al. – Although treatment of subclinical rejection with augmented immunosuppression has been associated with better graft survival, an increase of the immunosuppressive level to avoid subclinical rejection should be weighed against the risk of infection. The majority of viral infections affecting kidney allografts are caused by CMV and BKV. Antiviral CMV prophylaxis or pre–emptive therapy with ganciclovir has been shown to have beneficial effects in the pediatric renal transplant population. Treatment of BKV–induced nephropathy is based on reduction of the immunosuppressant therapy, although specific antiviral agents such as cidofovir and leflunomide are known to inhibit BKV.


Today in Pediatrics...keeping you current

Oral Ibuprofen and Ductus Arteriosus Closure in Full-Term Neonates: A Prospective Case-Control Study
Pediatric Cardiology, 10/30/09

Use of over-the-counter cough and cold medications in children
Canadian Family Physician, 11/13/09

Management of acute appendicitis: an imaging strategy in children
Pediatric Surgery International, 10/27/09


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