NP Medical News about Taxaceae Analgesics

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Appraisal of antinociceptive and anti-inflammatory potential of extract and fractions from the leaves of Torreya grandis Fort Ex. Lindl
Journal of Ethnopharmacology , 10/28/09

Saeed MK et al. – It was found that T. grandis extract and fractions at the doses of (100 and 200 mg/kg, i.g.) were significantly attenuated the writhing responses induced by acetic acid and second phase of pain response induced by sub plantar injection of formalin in mice. In addition, these extract and fractions inhibiting the formaldehyde–induced arthritis as well as xylene–induces edema prolifically. From acute oral toxicity studies no mortality was pragmatic even at highest dose (2500 mg/kg, i.g.). Furthermore, these phytochemical studies indicated that the aq. ethanolic extract of leaves contains alkaloids, flavonoids, tannins, terpenoids and saponins. The results provide justification for the folkloric uses of T. grandis in the treatment of analgesic and inflammatory–based diseases across the China.

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Factors associated with a continuous regular analgesic use - a population-based study of more than 45 000 Danish women and men 18-45 years of age
Pharmacoepidemiology and Drug Safety, 10/01/09 Relevance Score: 47%

Co-analgesics - today and tomorrow - A receptor-based overview of therapeutical options
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 11/17/09 Relevance Score: 45%

Clinical pharmacology of analgesics in old age and frailty
Reviews in Clinical Gerontology, 11/10/09 Relevance Score: 45%

Use of analgesic and sedative drugs in the NICU: integrating clinical trials and laboratory data
Pediatric Research, 11/09/09 Relevance Score: 45%

Diffuse analgesic effects of unilateral repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers
Pain, 10/13/09 Relevance Score: 44%