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Trans-10,cis-12 Conjugated Linoleic Acid Induces Depolarization of Mitochondrial Membranes in HT-29 Human Colon Cancer Cells: A Possible Mechanism for Induction of Apoptosis
Journal of Medicinal Food, 10/28/09

Cho HJ et al. – The findings indicate that physiological levels of t10c12 induce apoptosis in HT–29 colon cancer cells, which is mediated via mitochondrion–mediated events associated with a decline in Akt activity, an increase in the translocation of the pro–apototic Bad and Bax to the mitochondria, and the subsequent disruption of normal mitochondrial membrane potential.

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