NP Medical News about Onychomycosis

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In vitro activity of fluconazole, itraconazole, voriconazole and terbinafine against fungi causing onychomycosis
Clinical and Experimental Dermatology, 11/02/09

Mesa AC et al. – The aetiological agents of onychomycosis that found differ from those found in other countries, suggesting that the heat and humidity of the Colombian climate could favour yeast nail infections. The lowest MICs for Candida species may be explained by emerging resistant strains. Against dermatophytes, the lowest MICs were obtained with terbinafine, followed by voriconazole. MIC values for the evaluated agents were higher for non–dermatophyte filamentous fungi than for other fungi. As MIC breakpoints have not yet been established for onychomycosis therapies, it remains unclear if in vitro activities of antifungal drugs are predictive of clinical outcome.

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