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See Latest ArticlesEffects of steroid avoidance and novel protocols on growth in paediatric renal transplant patients
Pediatric Nephrology, 11/03/09
Grenda R – The Stanford study showed that a complete steroid avoidance under the “cover” of tacrolimus, mycophenolate mofetil and extended daclizumab induction is a very effective regimen for obtaining an improvement in post–transplantation growth. The recently reported international randomized TWIST trial demonstrated growth improvement as early as 6 months post–transplantation. These protocols may potentially enable paediatric renal graft recipients to safely avoid steroid exposure.
Ryszard Grenda, 11/04/09
| Steroid withdrawal is one of the most emerging medical approaches in pediatric transplantation. Risk-benefit ratio must be balanced in every individual case. Large clinical trials provide the best evidence and reliable information on efficacy and safety of minimizing protocols of immunosuppression. |
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