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See Latest ArticlesERK Involvement in Resistance to Apoptosis in Keratinocytes with Mutant Keratin
Journal of Investigative Dermatology, 10/23/09
Russell D et al. – The experiments show that mechanical stress activates extracellular signal–regulated kinase (ERK) signaling in these cells, and that the keratin mutant cells also show a resistance to apoptosis following mechanical stress that is reversed by inhibiting ERK. The consequences of constitutive expression of large amounts of defective structural protein in a tissue cell must be properly understood for the development of safe and effective therapies for these disorders.
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