NP Medical News about calcium oxalate stone

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Drug dosage protocol for calcium oxalate stone
Urological Research - Urolithiasis, 10/23/09

Marickar YMF et al. – In managing the stone patient, the clinical, radiological, microscopic and biochemical parameters should be taken into consideration in deciding the reduction/increase in the dose of drugs. The principle of giving chemotherapy/chemoprophylaxis should be to administer the least number of drugs in the least dosage depending upon the requirement of the disease.

Exclusive Author Commentary
Y. M. Fazil Marickar, 10/23/09

Many empirical drug managements are reported for stone patients. Most of these are unfortunately expensive, toxic, and ineffective. Non compliance is the end result. Appropriate drug selection and dosage scheduling will increase compliance and effectivity of treatment and reduce cost. Follow-up is essential with assessment of symptomatic relief, urine deposit pattern, stone passage rate and identification of radiological growth of stones. Combination of allopurinol and pyridoxine is found to be the sheet anchor of treatment of idiopathic calcium oxalate stone disease.

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