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Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
BMC: Journal of Biomedical Science, 10/19/09
Lin YR et al. – Honokiol was more selective than magnolol for inhibition of NMDA–induced licking behavioral and thermal hyperalgesia. In contrast, magnolol was more potent to block CHPG–mediated thermal hyperalgesia. These results demonstrate that honokiol and magnolol effectively decreased the inflammatory pain. Furthermore, their different potency on inhibition of nociception provoked by NMDA receptor and mGluR5 activation should be considered.
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