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Patients and physicians are confused by conflicting reports of the efficacy and safety of hormone therapy, both FDA–approved and non–FDA–approved bioidentical, as evidenced by the decline in women using hormone therapy despite their desire to continue therapy. A large percentage of postmenopausal women report being worried by news reports that the 2002 WHI report showed that hormone therapy is dangerous. Physicians report that the ambiguous and inconclusive results of the WHI reports sent mixed messages to physicians and patients that compromised physicians’ ability to discuss hormone therapy with their postmenopausal patients. Regardless of the type of preparation used, use of hormone therapy must consider the varying formulations available, pharmacodynamics, and individual patient factors.

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