NP Medical News about Crohn Disease Methotrexate

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Methotrexate for maintenance of remission in Crohn's disease
Cochrane Reviews, 10/27/09

Patel V et al. – This review shows that methotrexate (15 mg/week) injected intramuscularly (i.e. into muscles located in the arm or thigh) for 40 weeks is an effective treatment for preventing relapse (return of disease symptoms) among patients whose disease became inactive while taking higher doses of intramuscular methotrexate (25 mg/week). Side effects occurred in a small number of patients. These side effects are usually mild in nature and include nausea and vomiting, cold symptoms, abdominal pain, headache, joint pain and fatigue. Methotrexate (12.5 to 15 mg/week) taken orally has not been shown to be effective treatment for inactive Crohn's disease. However, there has been little study of this approach.

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