NP Medical News about Antihypertensive Agents Mortality Acute Coronary Syndrome

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Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event
Cochrane Reviews, 10/27/09

Perez MI et al. – Nitrates reduce mortality (4–8 deaths prevented per 1000) at 2 days when administered within 24 hours of symptom onset of an acute myocardial infarction. No mortality benefit was seen when treatment continued beyond 48 hours. Mortality benefit of immediate treatment with ACE inhibitors post MI at 2 days did not reach statistical significance but the effect was significant at 10 days (2–4 deaths prevented per 1000). There is good evidence for lack of a mortality benefit with immediate or short–term treatment with beta–blockers and calcium channel blockers for acute myocardial infarction.

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