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Efficacy and Safety Comparison Between the DPP-4 Inhibitor Vildagliptin and the Sulfonylurea Gliclazide After Two Years of Monotherapy in Drug-naive Patients with Type 2 Diabetes
Hormone and Metabolic Research, 08/26/09
Foley JE et al. – Vildagliptin monotherapy resulted in improved glycemic control in drug–naive patients with type 2 diabetes. Although the hypothesis of noninferiority to gliclazide was not borne out statistically, the reductions in HbA1c were similar over a two year period and vildagliptin had significant benefits in terms of less weight gain and less hypoglycemia.
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