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Serum Levels of Perfluorooctanoic Acid and Perfluorooctane Sulfonate and Pregnancy Outcome
American Journal of Epidemiology, 08/20/09
Stein CR et al. – Neither PFOA nor PFOS showed any association with miscarriage or preterm birth. Preeclampsia was weakly associated with PFOA and PFOS exposures above the median. PFOA was not associated with an increase in low birth weight, but PFOS showed an increased risk above the median and a dose–response gradient. Birth defects were weakly associated with PFOA exposures above the 90th percentile. This study identified modest associations of PFOA with preeclampsia and birth defects and of PFOS with preeclampsia and low birth weight, but associations were small, limited in precision, and based solely on self–reported health outcomes.
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