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See Latest ArticlesGenetic susceptibility to VTE: A primary care approach
JAAPA, 07/09/09
Ridings HD et al. - Approximately 30 conditions that increase the risk of venous thromboembolism (VTE), known as thrombophilias, have been identified. Some are relatively common and likely to be within the realm of primary care, whereas others are difficult to diagnose and require referral to a specialist. This variability and the risk involved with misdiagnosis demonstrate the need for primary care clinicians to be aware of these conditions as well as determine which patients should be referred to a hematologist. This article reviews the diagnostic tests for the seven most common genetic thrombophilic conditions, the pitfalls of testing, and the follow-up for patients who test positive for one or more of the thrombophilias. A discussion of drug management is limited because of the complexity and individualization required when treating patients with thrombophilia. In addition, acquired causes of VTE are discussed only in their roles as aggravating factors in patients with thrombophilia.
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