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A safety and tolerability laboratory study of the combination of aripiprazole and topiramate in volunteers who drink alcohol
Human Psychopharmacology: Clinical and Experimental, 06/26/09

Kenna GA et al. - There was no evidence that AEs of aripiprazole and topiramate are additive and can, therefore, be administered safely together with a modest amount of alcohol. There was also a trend for a reduction of alcohol use by participants. This finding has implications for further investigation of this combination of drugs for alcohol dependence.

Methods

Thirteen heavy drinking participants not seeking treatment for alcoholism were randomized.
Participants were titrated up to 300 mg of topiramate and 30 mg of aripiprazole a day over 35 days.
Participants reported adverse events (AEs) daily alcohol use and participated in an alcohol challenge session (ACS).

Results

The eight participants who completed the study achieved the maximum doses of drugs.
The AEs of the drugs would suggest that the AEs profile is broader but not additive.
Alcohol use from the 28 days before screening to the seven days before the ACS was reduced (p = 0.08).

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