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The Association Between Dementia and Long-Term Use of Benzodiazepine in the Elderly: Nested Case-Control Study Using Claims Data
American Journal of Geriatric Psychiatry, 07/01/09

Wu CS et al. - Findings suggest that long-term use of BZDs is associated with an increased risk for dementia, but the underlying mechanisms remain unclear, and further investigations are needed. Long-term use of BZDs should be avoided among the elderly, who may be at a higher risk for developing dementia, in addition to other health problems.

Methods

Cases (N = 779) were patients who were identified with dementia at least two times in their outpatient claims.
They were individually matched to six comparison subjects (N = 4,626) based on age and gender.
BZD usage (average dosage per year, average days per year, and cumulative dose and periods) and potential confounding comobidities, including cardiovascular and psychiatric diseases.

Results