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Warren JL et al. - The authors measured 30-day rates of cardiac and gastrointestinal events in a random sample of 53 220 Medicare beneficiaries who had outpatient colonoscopy and in a matched set of beneficiaries who did not. Rates were higher in colonoscopy patients, with advancing age and preexisting comorbid conditions (especially diabetes, heart failure, atrial fibrillation, stroke, and chronic obstructive pulmonary disease), and after polypectomy. This study concluded that risks for adverse events after outpatient colonoscopy among elderly Medicare beneficiaries were low; however, they increased with age with specific comorbid conditions and depending on whether polypectomy was done. These data may inform decisions on whether to perform colonoscopy in persons of advanced age or those with comorbid conditions.

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