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Nørskov-Lauritsen N et al. - Tigecycline, linezolid and vancomycin were the most active agents against Gram-positive agents across Europe between 2004 and 2007, with tigecycline displaying the lowest MIC90 values against meticillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium and penicillin-resistant Streptococcus pneumoniae. Longitudinal analysis showed no increase in tigecycline MIC values over the 4-year study period, whilst increased resistance was noted for several comparator agents.

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