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Nabilone produces marked impairments to cognitive function and changes in subjective state in healthy volunteers
Journal of Psychopharmacology, 06/18/09

Wesnes KA et al. - These data demonstrate that acute doses of nabilone in the range 1–3 mg produce clear cognitive and subjective effects in healthy volunteers, and therefore they may be used as reference data in the future study of peripherally acting cannabinoids believed to be free from such effects.

Methods

In addition, a number of self-ratings were conducted including those of mood, alertness and perceived drug effects. Impairments to attention, working and episodic memory and self-ratings of alertness were evident.

Results

These data demonstrate that acute doses of nabilone in the range 1–3 mg produce clear cognitive and subjective effects in healthy volunteers, and therefore they may be used as reference data in the future study of peripherally acting cannabinoids believed to be free from such effects.

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