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Lack of effect of citalopram on magnetic resonance spectroscopy measures of glutamate and glutamine in frontal cortex of healthy volunteers
Journal of Psychopharmacology, 06/12/09

Taylor MJ et al. - These data suggest that the effects of serotonin reuptake to modify cortical glutamatergic MRS measures may be regionally specific. This supports the potential for MRS in assessing neuroanatomically specific serotonin-glutamate interactions in the human brain.

Methods

Twenty-three healthy volunteers randomised to receive either citalopram 20 mg or a placebo capsule daily for 7-10 days were studied and scanned using a 3T Varian INOVA system before and at the end of treatment.
Standard short-TE (echo time) PRESS (Point-resolved spectroscopy) (TE = 26 ms) and PRESS-J spectra were acquired from a single 8-cm3 voxel in a frontal region incorporating anterior cingulate cortex.
Glutamate and total Glx levels were quantified both relative to creatine and as absolute levels.

Results

Relative to placebo, citalopram produced no change in Glx or glutamate alone at the end of the study.
no effect was seen on other MRS measures studied: myo-inositol, choline, N-acetylaspartate and creatine.

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