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The effects of polyunsaturated fatty acids on coronary disease
JAAPA, 03/23/09
Tabaka M - Based on the current literature, certain conclusions can be drawn: (1) moderate intake of fish oils appears to lower overall mortality in persons at higher risk for CAD during the period immediately following an MI; (2) the benefits of PUFAs are derived from their antiarrhythmic effects on the heart over and above any favorable effect they may have on serum lipids; (3) EPA and DHA supplements can significantly reduce cardiac related and all cause mortality, although the ideal dosages are as yet unclear. Since the discovery of the cardiac effects of PUFAs, interest in using them to treat and prevent CAD has increased. Although further studies are needed, sufficient justification exists to warrant at least discussing these benefits with appropriate patients. PAs should also be prepared to correct any misconceptions patients may have about the actual health benefits of PUFAs and to discuss the associated risks and possible unforeseen outcomes.
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