NP Medical News about systemic sclerosis;myocardial involvement

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Myocardial involvement in systemic sclerosis
Rheumatology, 06/20/08

Belloli L et al. – Myocardial perfusion defects in systemic sclerosis (SSc) patients are frequent, and the presence of severe skin thickness, digital ulcers and perhaps oesophageal involvement might warrant screening for myocardial involvement.

Methods

Study to identify clinical and/or laboratory characteristics that could be risk factors for myocardial microvascular involvement in SSc pts
21 SSc pts; clinically silent for cv disease; evaluated for myocardial perfusion defects
99m-Tc sestamibi gated myocardial perfusion SPECT with a stress–rest protocol was used

Results

38% of pts had myocardial perfusion defects
Perfusion defects were related to skin scores, digital ulcers, and oesophageal involvement
A trend for anti-Scl 70 antibody positivity was observed in these pts
3 SPECT-positive pts had re-establishment of normal myocardial perfusion after a course of prostanoid therapy
No associations between myocardial involvement and age, sex, diffuse/limited SSc, duration of RP or lung involvement

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