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Lowe, N.J., et al. - Dr Alan Scott's seminal investigations in the 1970s into the use of botulinum neurotoxin for strabismus represent the pivotal moment in its clinical research. In the decades that followed, botulinum neurotoxin was increasingly studied for therapeutic and aesthetic use. Currently, several botulinum neurotoxin products are available worldwide, with only a few investigated for cosmetic applications, and only one currently approved for facial aesthetic use in the United States

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