Neurology

Your Article Summary

See Latest Articles

Effect of certolizumab pegol with methotrexate on home and work place productivity and social activities in patients with active rheumatoid arthritis
Arthritis Care and Research , 11/02/09

Kavanaugh A et al. –The goal of this study was to assess the impact of certolizumab pegol (CZP), a novel PEGylated anti-tumor necrosis factor, in combination with methotrexate (MTX) on productivity outside and within the home, and on participation in family, social, and leisure activities in adult patients with RA. CZP plus MTX improved productivity outside and within the home and resulted in more participation in social activities compared with placebo plus MTX. These observations suggest that considerable indirect cost gains might be achieved with this therapeutic agent in RA.

• 2 phase III, multicenter, double-blind, placebo-controlled trials (Rheumatoid Arthritis Prevention of Structural Damage [RAPID] 1 and RAPID 2)
• Novel, validated, RA-specific Work Productivity Survey (WPS-RA) was used to assess work place and home productivity
• WPS-RA responses collected at baseline and every 4 weeks until withdrawal/study completion

• At baseline, 41.6% and 39.8% of subjects employed outside home in RAPID 1 and RAPID 2, respectively
• Compared with placebo plus MTX, CZP plus MTX significantly reduced work absenteeism and presenteeism among patients working outside home
• Significant reductions in number of household days lost, household days with productivity reduced by ≥ 50%, and days lost due to RA for participation in family, social, and leisure activities were reported by patients in active treatment relative to placebo plus MTX
• Improvements in all measures observed with CZP plus MTX as early as week 4, and maintained until study end
• Findings consistent with clinical improvements with CZP plus MTX in both trials

Today in Clinical Pharmacology...keeping you current

Receive free subspecialty "5-minute updates" via email

Olanzapine versus other atypical antipsychotics for schizophrenia
Cochrane Reviews, 03/19/10

Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Cochrane Reviews, 03/19/10

Fibrinolytic agents for peripheral arterial occlusion
Cochrane Reviews, 03/19/10

 See all of Clinical Pharmacology

Today in Clinical Pharmacology...keeping you current

Receive free subspecialty "5-minute updates" via email

Olanzapine versus other atypical antipsychotics for schizophrenia
Cochrane Reviews, 03/19/10

Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Cochrane Reviews, 03/19/10

Fibrinolytic agents for peripheral arterial occlusion
Cochrane Reviews, 03/19/10

 See all of Clinical Pharmacology

Today in Rheumatology...keeping you current

Receive free subspecialty "5-minute updates" via email

Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials
Osteoarthritis and Cartilage , 03/19/10

Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial
Osteoarthritis and Cartilage , 03/19/10

A review of the effect of anticonvulsant medications on bone mineral density and fracture risk
The American Journal of Geriatric Pharmacotherapy, 03/19/10

 See all of Rheumatology

Today in Rheumatology...keeping you current

Receive free subspecialty "5-minute updates" via email

Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials
Osteoarthritis and Cartilage , 03/19/10

A walking model to assess the onset of analgesia in osteoarthritis knee pain
Osteoarthritis and Cartilage , 03/19/10

Pegloticase for chronic gout
Cochrane Reviews, 03/19/10

 See all of Rheumatology

Today in Clinical Pharmacology...keeping you current

Receive free subspecialty "5-minute updates" via email

Olanzapine versus other atypical antipsychotics for schizophrenia
Cochrane Reviews, 03/19/10

Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Cochrane Reviews, 03/19/10

Fibrinolytic agents for peripheral arterial occlusion
Cochrane Reviews, 03/19/10

 See all of Clinical Pharmacology

Today in Clinical Pharmacology...keeping you current

Receive free subspecialty "5-minute updates" via email

Olanzapine versus other atypical antipsychotics for schizophrenia
Cochrane Reviews, 03/19/10

Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Cochrane Reviews, 03/19/10

Fibrinolytic agents for peripheral arterial occlusion
Cochrane Reviews, 03/19/10

 See all of Clinical Pharmacology

Today in Ortho/Rheum...keeping you current

Receive free subspecialty "5-minute updates" via email

Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials
Osteoarthritis and Cartilage , 03/19/10

Pegloticase for chronic gout
Cochrane Reviews, 03/19/10

A Systematic Review on the Effectiveness of the Nucleoplasty Procedure for Discogenic Pain
Pain Physician, 03/19/10

 See all of Ortho/Rheum

Today in Clinical Pharmacology...keeping you current

Receive free subspecialty "5-minute updates" via email

Olanzapine versus other atypical antipsychotics for schizophrenia
Cochrane Reviews, 03/19/10

Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Cochrane Reviews, 03/19/10

Fibrinolytic agents for peripheral arterial occlusion
Cochrane Reviews, 03/19/10

 See all of Clinical Pharmacology

Today in Rheumatology...keeping you current

Receive free subspecialty "5-minute updates" via email

Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials
Osteoarthritis and Cartilage , 03/19/10

A review of the effect of anticonvulsant medications on bone mineral density and fracture risk
The American Journal of Geriatric Pharmacotherapy, 03/19/10

Pegloticase for chronic gout
Cochrane Reviews, 03/19/10

 See all of Rheumatology

Today in Clinical Pharmacology...keeping you current

Receive free subspecialty "5-minute updates" via email

A review of the effect of anticonvulsant medications on bone mineral density and fracture risk
The American Journal of Geriatric Pharmacotherapy, 03/19/10

Severe exfoliative dermatitis caused by strontium ranelate: two cases of a new drug reaction
Age and Aging, 03/19/10

A walking model to assess the onset of analgesia in osteoarthritis knee pain
Osteoarthritis and Cartilage , 03/19/10

 See all of Clinical Pharmacology

Today in Rheumatoid Arthritis...keeping you current

Receive free subspecialty "5-minute updates" via email

Rheumatoid arthritis and autoimmune hemolysis: B-cell depletion for remission induction in a patient with rheumatoid arthritis and cold agglutinin disease
Zeitschrift für Rheumatologie, 03/19/10

Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA
Modern Rheumatology, 03/19/10

Decreased circulating CD28-negative T cells in patients with rheumatoid arthritis treated with abatacept are correlated with clinical response
Journal of Rheumatology, 03/19/10

 See all of Rheumatoid Arthritis