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Villa D et al. – The addition of rituximab to CHOP (R–CHOP; CHOP, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy improves outcome in patients with diffuse large B–cell lymphoma (DLBCL). The authors evaluated the risk of central nervous system (CNS) relapse in the R–CHOP in a population–based cohort of patients with DLBCL. The use of R–CHOP appears to reduce the overall risk of CNS relapse in patients with DLBCL particularly in patients who achieve a complete response.


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