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Use of Antidepressants for Management of Hot Flashes
Pharmacotherapy, 10/27/09

Carroll DG et al. – Data on the benefits with many of these agents are conflicting. Venlafaxine and paroxetine have been studied more extensively than any of the other antidepressants and are more consistent in effectively reducing the frequency and severity of hot flashes, based on these study results. Desvenlafaxine, sertraline, fluoxetine, and citalopram should be considered second– or third–line options if patients fail therapy with or cannot tolerate venlafaxine or paroxetine, based on the current published data. Duloxetine, escitalopram, fluvoxamine, and mirtazapine should be reserved as last–line therapy until more rigorous studies are conducted assessing their use in the management of hot flashes.

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Glutamate-based antidepressants: 20 years on
Trends in Pharmacological Sciences, 10/29/09 Relevance Score: 66%

Synaptic Adaptations of CA1 Pyramidal Neurons Induced by a Highly Effective Combinational Antidepressant Therapy
Biological Psychiatry, 11/18/09 Relevance Score: 65%

The Role of Sodium Channels in the Mechanism of Action of Antidepressants and Mood Stabilizers
Current Drug Targets, 10/30/09 Relevance Score: 64%

Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes
Journal of Pharmacology and Experimental Therapeutics, 10/26/09 Relevance Score: 64%

Early induction of CREB activation and CREB-regulating signalling by antidepressants
International Journal of Neuropsychopharmacology, 10/21/09 Relevance Score: 64%